The Museum of the Llano Estacado, located on the campus of Wayland Baptist University in Plainview, is dedicated to the regional history and pre-history of the Llano Estacado, also known as the Southern High Plains, one of the continent’s largest geographic mesas. The museum explores the region’s geology, including examples of the local minerals and rocks, along with fossils. An impressive exhibit of the mesa’s Pleistocene era features a sizable mammoth skull.

In other exhibits, centuries-old helmets, swords, and spurs date to Spanish explorations beginning with Coronado's search for the seven cities of gold in the mid-1500s. Trade items discovered in this region from Comancheros—Hispanic traders who worked with area tribes—are also on display.

The museum also depicts the settlement of the Plains with a reproduction of a mercantile store, jailhouse, and doctor’s office. Once a vast free range, the Llano Estacado was eventually crosshatched by fences and railroads and the museum depicts the region’s period of ranching and railway history with a tack room, a blacksmith shop, a watering tank and a wooden windmill. The turn-of-the-century, exemplified by the trappings of the Victorian era, is well-represented in the museum’s collection of fully-furnished period rooms including a parlor, bedroom, and drawing room.