Opened in 1929, the La Salle Hotel was the tallest building in downtown Bryan, Texas. Only a short walk from the Bryan railroad station, the hotel catered to guest traveling between Houston and Dallas by rail. The hotel featured 100 guest rooms, a ballroom, and meeting space. The building is an architectural landmark representative of the city's early 20th century commercial development

In 1934 the hotel was converted into a home for Civil War survivors. Over the years the building also served as a nursing home and an apartment building. You might also have heard it mentioned in the song "The Front Porch", written by Texas musicians Robert Earl Keen and Lyle Lovett.

Renovations began on the building in 1997, and in 2000 the La Salle Hotel was re-opened to travelers as a boutique hotel. The renovation served as the catalyst for the revitalization of downtown Bryan. Also in the year 2000, the La Salle Hotel was listed on the National Register of Historic Places for its significance to the City of Bryan and the downtown district. The hotel was further renovated during 2015, and today features 55 rooms and suites, a cocktail bar (Downtown Elixir), and a speakeasy (5 Knocks Speakeasy).